TGF-beta and cancer

Isabel Fabregat

PRINCIPAL INVESTIGATORS
  • Angels Fabra Fres
CLINICAL RESEARCHERS
  • Josep Ramon Ferreres Riera
POSTDOCTORAL RESEARCHERS (R2)
  • Noel Pérez Fusté
  • Javier Vaquero Rodriguez
  • Maria Esther González Sanchez
PREDOCTORAL RESEARCHERS (R1)
  • Irene Peñuelas Haro
  • Macarena Herranz Iturbide
  • Rut Espinosa Sotelo
SCIENTIFIC SUPPORT
  • Antonia Vinyals Rioseco
  • Esther Bertran Rodriguez
  • Raquel Ramos Martín
Cancer
Oncobell

Scientific production

5

PAPERS

3 PUBLICATIONS IN FIRST QUARTILE

Selected publications

  • López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E, Sanz-Moreno V, Fabregat I . Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition.. CANCER LETTERS. 10.1016/j.canlet.2019.08.011
  • Modica TME, Dituri F, Mancarella S, Pisano C, Fabregat I, Giannelli G . Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC.. CANCERS. 10.3390/cancers11101588
  • Almalé L., García-Álvaro M., Martínez-Palacián A., García-Bravo M., Lazcanoiturburu N., Addante A., Roncero C., Sanz J., de la O López M., Bragado P., Mikulits W., Factor V., Thorgeirsson S., Casal J., Segovia J., Rial E., Fabregat I., Herrera B., Sánchez A.. c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-?-Induced Epithelial–Mesenchymal Transition and Regulates Cell Phenotypic Switch. STEM CELLS. 10.1002/stem.3038
  • Campisano S, Bertran E, Caballero-Díaz D, La Colla A, Fabregat I, Chisari AN . Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation.. BIOCHIMICA ET BIOPHYSICA ACTA – GENERAL SUBJECTS. 10.1016/j.bbagen.2019.01.017
  • Matas-Nadal C, Malvehy J, Ferreres JR, Boada A, Bodet D, Segura S, Salleras M, Azon A, Bel-Pla S, Bigata X, Campoy A, Curcó N, Dalmau J, Formigon M, Gonzalez A, Just M, Llistosella E, Nogues ME, Pedragosa R, Pujol JA, Sabat M, Smandia JA, Zaballos P, Puig S, Martí RM . Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.. INTERNATIONAL JOURNAL OF DERMATOLOGY. 10.1111/ijd.14334

Research highlights

PROJECTS

5 Ongoing projects

2 Started projects

INNOVATION

1 license

Selected projects

  • Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneración y cáncer hepáticos. Relación con la vía del TGF-beta. (1/1/2019 – 31/12/2021) PI: FABREGAT ROMERO, ISABEL. Funder: AEI – MINISTERIO DE CIENCIA E INNOVACIÓN.
  • Vias de diseminación metastásica en distintos subtipos del melanoma maligno: nuevos biomarcadores tumorales y dianas terapéuticas (1/1/2016 – 31/12/2020) PI: FABRA FRES, ANGELS. Funder: ASOCIACION ESPAÑOLA CONTRA EL CANCER.
  • Uveal melanoma and liver metastasis:predictive use of molecular alterations and therapeutic opportunities (1/1/2019 – 31/12/2021) PI: FABRA FRES, ANGELS. Funder: FIS-Instituto de Salud Carlos III.