Chemoresistance and Predective Factors to Tumor Response and Stromal Microenvirontment
PRINCIPAL INVESTIGATORS
- Maria Lourdes Farre Vallve
POSTDOCTORAL RESEARCHERS (R2)
- Samuel Gonçalves Ribeiro
PREDOCTORAL RESEARCHERS (R1)
- Juan Francisco Martín Tejera
- Nerea Albert Colome
- Gemma Garcia Vicien
SCIENTIFIC SUPPORT
- Monica Calaf Sanjuanes
- Maria Bañuls Ferrando
Cancer
Oncobell
Scientific production
12
PAPERS
7 PUBLICATIONS IN FIRST DECILE
9 PUBLICATIONS IN FIRST QUARTILE
Selected publications
- Etxeberria I, Bolaños E, Quetglas JI, Gros A, Villanueva A, [15authors] Sanmamed MF, Inogés S, Berraondo P, Teijeira Á, Melero I . Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells.. CANCER CELL. 10.1016/j.ccell.2019.10.006
- Janin M., Ortiz-Barahona V., de Moura M.C., Martínez-Cardús A., Llinàs-Arias P., [42 authors], Blanco S., Seoane J., Preiss T., Pandolfi P.P., Esteller M.. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. ACTA NEUROPATHOLOGICA. 10.1007/s00401-019-02062-4
- Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, [10 authors], Gentilella A, Villanueva A, Esteller M, Farré L, Guil S . The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.. NATURE COMMUNICATIONS. 10.1038/s41467-019-11910-6
- Guillén Díaz-Maroto N, Sanz-Pamplona R, Berdiel-Acer M, Cimas FJ, García E, Gonçalves-Ribeiro S, Albert N, Garcia-Vicién G, Capella G, Moreno V, Salazar R, Villanueva A, Molleví DG . Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer.. CLINICAL CANCER RESEARCH. 10.1158/1078-0432.CCR-18-3957
- Batista E.S., Oliveira P.D., Primo J., Varandas C.M.N., Nunes A.P., Bittencourt A.L., Farre L.. HTLV-1 proviral load in infective dermatitis associated with HTLV-1 does not increase after the development of HTLV-1-associated myelopathy/tropical spastic paraparesis and does not decrease after IDH remission. PLOS NEGLECTED TROPICAL DISEASES. 10.1371/journal.pntd.0007705
Research highlights
PROJECTS
8 Ongoing projects
2 Started projects
INNOVATION
1 spin-off
1 license
Selected projects
- EDIReX:EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts (1/2/2018 – 31/1/2022) PI: VILLANUEVA GARATACHEA, ALBERTO. Funder: COMUNITAT EUROPEA.
- Generation of personal derived orthotopic xenografts (PDOX) of bladder cancer as advanced preclinical tumor models to improve patients treatment (1/12/2018 – 30/11/2020) PI: VILLANUEVA GARATACHEA, ALBERTO. Funder: ASOCIACION ESPAÑOLA CONTRA EL CANCER.
- PORTAL:Personalized oncology for refractory and relapsed lymphoma using humanized patient derived othotopic xenografts (ImmunePDOX) (1/4/2018 – 31/3/2020) PI: FARRE VALLVE, MARIA LOURDES. Funder: COMUNITAT EUROPEA.
- Identificación de un “core genético básico” de adquisición de resistencia al cisplatino en orthoxenografts® de tumores de pulmón (NSCLC), epiteliales de ovario y germinales testiculares (1/1/2017 – 31/12/2019) PI: VILLANUEVA GARATACHEA, ALBERTO. Funder: FIS-Instituto de Salud Carlos III.
- Biomarcadors estromals predictors de resposta al tractament en carcinoma pancreàtic metastàsic. (24/4/2017 – 31/12/2019) PI: GARCIA MOLLEVI, DAVID. Funder: DEPARTAMENT SALUT (PR).