Metabolism and cancer

George Thomas

RESEARCH EMERITUS
  • Sara Catherine Kozma
PRINCIPAL INVESTIGATORS
  • Albert Tauler Girona
  • Antonio Gentilella
POSTDOCTORAL RESEARCHERS (R2)
  • Ana Domostegui Fernandez
  • Joffrey Pelletier
  • Caroline Mauvezin
  • Maria Teresa Rubio Lopez
PREDOCTORAL RESEARCHERS (R1)
  • Eugenia Almacellas Canals
  • Francisco David Moron Duran
  • Flavia Iannizzotto
  • Carolina Martínez Herráez
SCIENTIFIC SUPPORT
  • Marta Garcia Cajide
  • Aina Lluch Balaña
Cancer
Oncobell

Scientific production

4

PAPERS

3 PUBLICATIONS IN FIRST DECILE

*Average Journal IF

3 PUBLICATIONS IN FIRST QUARTILE

Selected publications

  • Morcelle C, Menoyo S, Morón-Duran FD, Tauler A, Kozma SC, Thomas G, Gentilella A . Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content.. CANCER RESEARCH. 10.1158/0008-5472.CAN-18-2718
  • Almacellas E., Pelletier J., Manzano A., Gentilella A., Ambrosio S., Mauvezin C., Tauler A.. Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1. ISCIENCE. 10.1016/j.isci.2019.09.040
  • Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, Boque-Sastre R, Calleja-Cervantes ME, Castro de Moura M, Martínez-Cardús A, Rubio T, Pelletier J, Martínez-Iniesta M, Herrero-Martín D, Tirado OM, Gentilella A, Villanueva A, Esteller M, Farré L, Guil S . The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.. NATURE COMMUNICATIONS. 10.1038/s41467-019-11910-6
  • Janin M., Ortiz-Barahona V., de Moura M.C., Martínez-Cardús A., Llinàs-Arias P., [45 authors] Blanco S., Seoane J., Preiss T., Pandolfi P.P., Esteller M.. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. ACTA NEUROPATHOLOGICA. 10.1007/s00401-019-02062-4

Research highlights

PROJECTS

8 Ongoing projects
1 Started projects 

PUBLISHED WORKS

1 Thesis

Selected projects

  • Laboratory of Cancer Metabolism (LMC) (1/1/2018 31/12/2020) PI: GENTILELLA, ANTONIO. Funder: AGAUR-GENERAL.CATALUNYA.
  • Papel de los complejos 40S-LARP1 y IRBC en el cancer colorectal dirigido por c-myc. (1/1/2018 – 31/12/2020) PI: GENTILELLA, ANTONIO. Funder: MINISTERIO DE EDUCACION Y CIENCIA.
  • Alteración de la actividad v-ATPasa y el tráfico lisosomal como terapia contra el cáncer (1/1/2018 – 31/12/2020) PI: TAULER GIRONA, ALBERT. Funder: MINISTERIO DE EDUCACION Y CIENCIA.
  • New therapeutic strategies for resistant colorectal cancer (1/4/2015 – 31/3/2020) PI: THOMAS , GEORGE. Funder: ASOCIACION ESPAÑOLA CONTRA EL CANCER.
  • Assessment of the Efficacy of Combining RAD001 and MLN0128, in Human Hepatocellular Carcinoma (HCC). (17/3/2016 – ) PI: Kozma, Sara Catherine. Funder ref.: TAKEDA Pharmaceuticals.